Cambridge Diabetes Risk Score

Cambridge Diabetes Risk
Age
Sex
Prescribed steroids
Family history of diabetes
BMI
Smoking status
Antihypertensive medication
Cambridge Score:0
Predicts risk of having previously undiagnosed type 2 diabetes.

Why Use

Most diabetes risk scores are validated against an outcome of clinically diagnosed diabetes rather than using a design in which the whole study population undergoes the diagnostic test. This leads to bias, as the variables included in risk scores are related to the patient characteristics likely to encourage doctors to undertake diagnostic testing. The Cambridge Diabetes Risk Score is validated in populations that underwent diagnostic testing to reduce this bias.

Formula

Probability of having T2DM (HgbA1c ≥7.0%) = 1 / (1 + e -(α + β 1 x 1 + β 2 x 2 + β 3 x 3 +...+ β n x n ) ) Where: α = -6.322, and additional constants and variables are as follows: β x 1. Gender -0.879 0 if Male 1 if Female 2. Prescribed antihypertensive medication 1.222 0 if No 1 if Yes 3. Prescribed steroids 2.191 0 if No 1 if Yes 4. Age 0.063 Age in years 5. BMI, kg/m 2 β 5 x 5 = 0 if <25 β 5 x 5 = 0.699 if ≥25 and <27.5 β 5 x 5 = 1.97 if ≥27.5 and <30 β 5 x 5 = 2.518 if ≥30 6. Family history β 6 x 6 = 0 if no diabetic 1st-degree relative β 6 x 6 = 0.728 if parent or sibling with diabetes β 6 x 6 = 0.753 if parent and sibling with diabetes 7. Smoking history β 7 x 7 = 0 if non-smoker β 7 x 7 = -0.218 if ex-smoker β 7 x 7 = 0.855 if current smoker

Advice

Guidelines vary, but the threshold for formal screening should be lower in patients with higher risk for undiagnosed diabetes.

More Information

Interpretation: Griffin score cutoff Sensitivity Specificity Positive predictive value Negative predictive value 0.11 85% 51% 2.2% 99.6% 0.15 72% 60% 2.2% 99.4% 0.17 70% 64% 2.4% 99.4% 0.23 63% 72% 2.8% 99.4% 0.29 51% 78% 2.9% 99.2%

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