DSM-5 Criteria for Major Depressive Disorder

DSM-5 Criteria for Major Depressive Disorder (must have all A-E below): Criteria A. Depressive symptoms: ≥5 symptoms during the same two week period that are a change from previous functioning. Depressed mood (#1) and/or loss of interest/pleasure (#2) must be present. Exclude symptoms clearly attributable to another medical condition. Depressed mood. Most of the day, nearly every day. May be subjective (e.g. feels sad, empty, hopeless) or observed by others (e.g. appears tearful). In children and adolescents, can be irritable mood. Loss of interest/pleasure. Markedly diminished interest/pleasure in all (or almost all) activities most of the day, nearly every day. May be subjective or observed by others. Weight loss or gain. Significant weight loss (without dieting) or gain (change of >5% body weight in a month), or decrease or increase in appetite nearly every day. In children, may be failure to gain weight as expected. Insomnia or hypersomnia. Nearly every day. Psychomotor agitation or retardation. Nearly every day and observable by others (not merely subjectively restless or slow). Fatigue. Or loss of energy, nearly every day. Feeling worthless or excessive/inappropriate guilt. Nearly every day. Guilt may be delusional. Not merely self reproach or guilt about being sick. Decreased concentration. Nearly every day. May be indecisiveness. May be subjective or observed by others. Thoughts of death/suicide. Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without specific plan, or suicide attempt, or a specific plan for suicide. B. Symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning. C. Episode not attributable to physiological effects of a substance or another medical condition. D. Episode not better explained by schizoaffective disorder, schizophrenia, schizophreniform disorder, delusional disorder, or other specified and unspecified schizophrenia spectrum and other psychotic disorders. E. No history of manic or hypomanic episode (exclusion does not apply if all manic-like or hypomanic-like episodes are substance-induced or are attributable to physiological effects of another medical condition).