SLICC Criteria for Systemic Lupus Erythematosus (SLE) 2012

SLE diagnosis is positive if patient has: Biopsy-proven nephritis compatible with SLE and ANA or anti-dsDNA antibodies Or: ≥4 of the criteria below at any time including at least one clinical criterion and one immunological criterion. Clinical criteria (≥1 must be present): Criteria Acute cutaneous lupus Lupus malar rash (not malar discoid) Bullous lupus Toxic epidermal necrolysis variant of SLE Maculopapular lupus rash Photosensitive lupus rash (not dermatomyositis) Subacute cutaneous lupus (nonindurated psoriasiform and/or annular polycyclic lesions that resolve without scarring, although occasionally with postinflammatory dyspigmentation or telangiectasias) Chronic cutaneous lupus Localized (above the neck) and/or generalized (above and below the neck) classical discoid rash Hypertrophic (verrucous) lupus Lupus panniculitis (profundus) Mucosal lupus Lupus erythematosus tumidus Chilblains lupus Discoid lupus/lichen planus overlap Oral ulcers (in absence of other causes) Palate Buccal Tongue Nasal ulcers Nonscarring alopecia (in absence of other causes) Synovitis involving ≥2 joints, characterized by swelling or effusion OR tenderness in ≥2 joints and 30 mins or more of morning stiffness Serositis Typical pleurisy for >1 day, pleural effusions, or pleural rub Typical pericardial pain for >1 day, pericardial effusion, pericardial rub, or pericarditis by EKG (in absence of other causes) Renal Urine protein/creatinine (or 24 hr urine protein) representing 500 mg of protein/24 hr RBC casts Neurologic Seizures Psychosis Mononeuritis multiplex (in absence of other causes) Myelitis Peripheral or cranial neuropathy (in absence of other causes) Acute confusional state (in absence of other causes) Hemolytic anemia (in absence of other causes) Leukopenia (<4,000/mm³ at least once) or lymphopenia (<1,000/mm³ at least once) in absence of other causes Thrombocytopenia (<100,000/mm³ at least once) in absence of other causes Immunological criteria (≥1 must be present): Criteria ANA above laboratory reference range Anti-dsDNA above laboratory reference range, except ELISA (2x above laboratory reference range) Anti-Sm Antiphospholipid antibody Lupus anticoagulant False positive RPR Medium or high titer anticardiolipin (IgA, IgG or IgM) Anti-β 2 glycoprotein (IgA, IgG or IgM) Low complement Low C3 Low C4 Low CH50 Positive direct Coombs test (in the absence of hemolytic anemia)