LENT Prognostic Score for Malignant Pleural Effusion

LENT Calculator
L – Pleural Fluid LDH (IU/L)
E – ECOG Performance Status
N – Neutrophil-to-Lymphocyte Ratio
T – Tumor Type
LENT Score: 0
Low Risk
0 points: Low risk. Median survival 319 days.
Predicts survival in patients with malignant pleural effusion.

Why Use

Survival for patients with malignant pleural effusion (MPE) is variable, and treatment is invasive, uncomfortable, and affects quality of life. Better understanding of survival can help inform treatment decisions.

Formula

Addition of the selected points: Points 0 1 2 3 Pleural fluid LDH, U/L <1,500 ≥1,500 -- -- ECOG Score 0 (asymptomatic) 1 (symptomatic but ambulatory) 2 (symptomatic, in bed <50% of day) 3–4 (symptomatic, in bed >50% of day or bedbound) Serum neutrophil-to-lymphocyte ratio <9 ≥9 -- -- Tumor type Mesothelioma or hematologic malignancy Breast or gynecologic cancer or RCC Lung or any other cancer --

Management

Consider prognosis in discussion of treatment options. Patients with high risk and low predicted survival may opt for permanent indwelling pleural catheter or therapeutic aspiration for minimizing hospital stay versus attempted pleurodesis.

Advice

For patients in whom malignant status is suspected, Light’s Criteria may provide initial confirmation before definitive diagnosis. Consider palliative care consultation for patients with metastatic disease.

More Information

Interpretation: LENT Score Risk Median survival 0–1 Low 319 days 2–4 Moderate 130 days 5–7 High 44 days

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