Overall Neuropathy Limitations Scale (ONLS)
Why Use
The ONLS allows semi-objective measurement of function, which is useful to detect changes with therapy, and relatively earlier changes may be detected than on the standard five-point Medical Research Council scale used in routine examination of muscle power.
When to Use
Specifically validated in peripheral neuropathies, particularly immune-mediated types (GBS, CIDP and paraprotein-associated demyelinating neuropathies). Non-neuropathic conditions that affect function (e.g. arthritis) should be considered and not scored. Not validated for use in children, and should be applied to adult patients only.
Formula
Pearls / Pitfalls
Used to quantify functional disability relating to peripheral neuropathy, particularly to assess progression over time or response to treatment. The ONLS is essentially a modified ODSS (Overall Disability Sum Score), which was derived from a tool at Guy’s Hospital for assessing patients with multiple sclerosis. Involves primarily assessment of function, with grades 0-5 in the arms and 0-7 in the legs (higher numbers indicate worse function), and a total score of 0-12 allowing broad assessment of a patient’s disability (the original ODSS graded lower limb function as zero if walking was not affected, whereas the ONLS reduces the ceiling effect by requiring the additional tasks of running and climbing stairs to be unaffected). May not be as responsive to changing symptoms in neuropathies without a significant motor component (e.g. DADS-M). Best used when combined with direct questions of the patient and direct observation of function.
Advice
The total score 0-12 provides an overall measure of the current disability relating to the patient’s neuropathy, and comparison to previous scores (or future) allows objective tracking of progress over time.
More Information
The Overall Neuropathy Limitations Scale (ONLS) Score ranges from 0 (no disability) to 12 (maximum disability).