Manchester Score for Prognosis in Small Cell Lung Cancer
Manchester Score for SCLC Calculator
LDH (Abnormal / Elevated)
Sodium <132 mmol/L
Alkaline Phosphatase (Abnormal / Elevated)
Karnofsky Performance Status <60
Bicarbonate <24 mmol/L
Manchester Score:
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Awaiting input
Select all criteria to compute the score.
Predicts 2 year survival of small cell lung cancer.
When to Use
It has been used to determine when to administer chemotherapy in the ICU to admitted lung cancer patients.( Zarogoulidis 2013 )
Formula
Addition of assigned points. If Karnofsky Performance Scale <60, item is assigned 1 point.
Pearls / Pitfalls
The score distinguishes three prognostic groups with overall two-year survival rates of 16.2%, 2.5%, and 0%.
Advice
The scoring system may help in the design of new treatment strategies and may assist in the comparison of different studies.
More Information
Original Study: 407 patients with SCLC, seen between 1979 and 1985. All patients received short-term intensive regimens (cyclophosphamide, etoposide and methotrexate or ifosfamide and etoposide, both followed by thoracic irradiation if complete response was noted). Manchester score Prognostic group Two year survival (%) ≤1 Good 16.2 2 - 3 Medium 2.5 ≥4 Poor 0