Lille Model for Alcoholic Hepatitis
Lille Model Calculator
years
g/dL
mg/dL
mg/dL
mg/dL
seconds
Renal Insufficiency
Result:
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Predicts mortality in patients with alcoholic hepatitis not responding to steroid therapy.
When to Use
Identification of patients with alcoholic hepatitis not responding to steroids who should be considered for alternative therapies or early referral for transplant.
Formula
Lille Model Score = (exp(-R))/(1 + exp(-R)) where the variables are as follows: R = 3.19 – 0.101*(age, years) + 0.147*(albumin day 0, g/L) + 0.0165* (evolution in bilirubin level, µmol/L) – 0.206*(renal insufficiency) – 0.0065*(bilirubin day 0, µmol/L) – 0.0096*(PT, sec) Renal insufficiency = 1 (if Cr >1.3 mg/dL (115 µmol/L)) or 0 (if ≤1.3 mg/dL (115 µmol/L))
Advice
It is known that not all patients with alcoholic hepatitis will respond to steroids, but was not previously known which of the non-responders would have a poor prognosis; the Lille Model helps determine this.
More Information
The Lille Model predicts mortality rates within 6 months. Scores >0.45 predict a 6-month survival of 25%. Scores <0.45 predict a 6-month survival of 85%.