Fatty Liver Index - CliniDeck

Fatty Liver Index Calculator

BMI

kg/m²

Waist Circumference

Triglycerides

mg/dL

GGT

U/L

Diagnoses fatty liver using labs and exam findings.

Why Use

May help in patient selection for ultrasound or liver biopsy. Validated in multiple external cohorts. May be used in the research setting to identify patients for planning observational or interventional studies.

When to Use

Patients in whom fatty liver (e.g. alcoholic fatty liver, NAFLD, NASH) is suspected.

Formula

Fatty Liver Index (FLI) = e y / (1 + e y ) × 100 Where y = 0.953 × ln(triglycerides, mg/dL) + 0.139 × BMI, kg/m 2 + 0.718 × ln (GGT, U/L) + 0.053 × waist circumference, cm – 15.745

Pearls / Pitfalls

Among liver enzymes, GGT was the only independent predictor of fatty liver in the original study, though it is not always part of routine liver enzymes across settings. Originally derived in a Northern Italian cohort but has since been validated in multiple cohorts including North America, China, and the UK.

Advice

Consider ultrasound for confirmation/clarification in patients with indeterminate or high FLI.

More Information

Interpretation: Fatty Liver Index Risk Diagnosis <30 Low Fatty liver ruled out (LR- = 0.2) 30 to <60 Indeterminate Fatty liver neither ruled in nor ruled out ≥60 High Fatty liver ruled in (LR+ = 4.3)