Metroticket Calculator for Hepatocellular Carcinoma (HCC) Survival

Why Use

Allows patients who don't fit the original Milan Criteria to be considered for transplantation with similar predicted survival benefit. Offers potential curative option for patients who don't meet the Milan criteria.

When to Use

Derived in order to explore whether certain patients not fulfilling Milan Criteria could potentially benefit from liver transplant. Similar survival as Milan criteria if criteria are expanded to Up-to-Seven(size of largest tumor in cm + number of tumors ≥7). Not as widely used or validated as the original Milan criteria. Tumor grade was not included as a prognostic factor, though it is known to correlate with survival. The authors cited a high number of patients missing data on tumor grade (28.5%) and used vascular invasion as an alternate pathologic parameter.

Formula

Pearls / Pitfalls

Patients with HCC not fulfilling Milan Criteria but who may be considered for transplant with similar benefit.

Advice

For patients who fail to meet the Milan Criteria but fulfill the up-to-seven criteria, consider transplant evaluation.

More Information

For more information on the Metroticket calculators, visit the Metroticket Project website .